Case control study design in epidemiology

Why do we use random allocation? At the end of the follow-up period, investigators found the lowest incidence of diabetes in the lifestyle intervention group, the next lowest in the anti-diabetic drug group, and the highest in the placebo group. This section also covers: Since case-control studies start with people known to have the outcome rather than starting with a population free of disease and waiting to see who develops it it is possible to enroll a sufficient number of patients with a rare disease.

It has been said that epidemiology by itself can never prove that a particular exposure caused a particular outcome. The " case-control " study.

Case–control study

The case-control design also is the most practical option for studying exposure related to rare diseases. Case-control studies are sometimes less valued for being retrospective.

Case Control Study

Common sources of bias in a case-control study 3. That is in part because known cases can be compared with selected controls as opposed to waiting for cases to emerge, which is required by other observational study designs and in part because of the rare disease assumption, in which OR mathematically becomes an increasingly better approximation of relative risk as disease incidence declines.

This means that like a detective you begin at the end, with the disease, and then work backwards, to hunt for possible causes. Further investigation of the ingredients in the salsa implicated green onions as the source of infection.

Occasionally, a placebo or sham treatment will be used in the control group, but where there is already an accepted treatment, it is unlikely to be ethical to use a placebo. Fictitious Example There is a suspicion that zinc oxide, the white non-absorbent sunscreen traditionally worn by lifeguards is more effective at preventing sunburns that lead to skin cancer than absorbent sunscreen lotions.

This will give you a low estimate of prevalence, unless you follow them for so long that all the prevalent cases you excluded will have died anyway.

On the other hand, research and academic organizations are more likely to conduct studies of cancer, cardiovascular disease, and other chronic diseases which may last for years and even decades. Care must be taken to be objective in the search for past risk factors, especially since the outcome is already known, or the study may suffer from researcher bias.

Analysis; Odds Ratios and Confidence Intervals In the analysis stage, calculate the frequency of each of the measured variables in each of the two groups. Differences in exposure prevalence between the case and control groups allow investigators to conclude that the exposure is associated with the disease.

If the amount of exposure among the case group is substantially higher than the amount you would expect based on the control group, then illness is said to be associated with that exposure.

Population based case control studies are generally more expensive and difficult to conduct. Random allocation means allocating them by chance e. As a measure of the strength of the association between an exposure and the outcome, case-control studies yield the odds ratio.

Sometimes they are the only ethical way to investigate an association. Here, you draw a random sample of people and record information about their health in a systematic manner.

In these, there is an intervention, but it is often not completely planned by the person doing the research. This study used a matched design, matching infants who had persistent pulmonary hypertension with infants who did not have it, and compared the rates of exposure to SSRIs.

Introduction to study designs - case-control studies

Controls Controls should be chosen who are similar in many ways to the cases.Often called “the cornerstone” of public health, epidemiology is the study of the distribution and determinants of diseases, health conditions, or events among populations and the application of that study to control health problems.

The study of hepatitis A traced to green onions, described above, is an example of a case-control study. The key in a case-control study is to identify an appropriate control group, comparable to the case group in most respects, in order to provide a reasonable estimate of the baseline or expected exposure.

More chapters in Epidemiology for the uninitiated. Case-control studies.

Cohort Study

As discussed in the previous chapter, one of the drawbacks of using a longitudinal approach to investigate the causes of disease with low incidence is that large and lengthy studies may be required to give adequate statistical power.

Cohort studies and case-control studies are two primary types of observational studies that aid in evaluating associations between diseases and exposures. In this review article, we describe these study designs, methodological issues, and provide examples from the plastic surgery literature.

A case-control study is designed to help determine if an exposure is associated with an outcome (i.e., disease or condition of interest). In theory, the case-control study can be described simply. First, identify the cases (a group known to have the outcome) and the controls (a.

Case-control studies are one of the frequently used study designs due to the relative ease of its application in comparison with other study designs.

This section introduces you to basic concepts, application and strengths of case-control study.

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Case control study design in epidemiology
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